SUNLIGHT (Study Using Neurovascular Longitudinal Insights to Guide Head injury Treatment) is a prospective observational study using quantitative MRI techniques to assess neurovascular injury after traumatic brain injury (TBI), with a view to determining a subgroup of individuals for a future precision medicine trial. This study contributes to the MRC-funded Ìýresource.
Funded by Ìýand the .
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The Southampton Clinical and Experimental Neurology Team co-led a national surveillance effort to monitor the neurological complications of COVID-19 (CoroNerve Studies Group). Together with colleagues in the Universities of Liverpool and Newcastle and University College London, a diverseÌýrange ofÌýphysician specialist associations UK-wide, and hundreds of case notifiers, we studied the neurological and neuropsychiatric sequelae of COVID-19.
Funded by the University of Southampton, the Ìýand .
National rapid case notification study
We helped interpret patterns of neurological COVID-19 cases reported by physicians to their specialist associations. AÌýclear pattern emerged of a wide spectrum of neurological involvement, and we have published our findings in . In addition to conventional autoimmune post-infectious syndromes affecting central and peripheral nervous systems, a number of para-infectious and post-infectious neurological syndromes were encountered including cerebrovascular disease syndromes and altered mental states. These required further detailed clinical phenotyping.
Deep phenotyping
In collaboration with reporting physicians, rapid case notification was followed byÌýanalysisÌýof detailed demographic, clinical, laboratory, radiological, treatment modalities and outcome data. The aim was to differentiate causality from association, recognize patterns in neurological syndromes, identify risk factors for neurological involvement during COVID-19, establish prognostic factors for long-term clinical outcome and inform refinement of acute clinical care protocols.ÌýThe Ìý(CIRU),Ìýbased within the Faculty of Medicine, developed a national case report form which wasÌýhosted on theÌýALEAÌýplatform. Our findings have been published in .
Prevention
In collaboration with , we investigated the efficacy of dexamethasone and remdesivir in preventing neurological complications of COVID-19.ÌýOur findings have been published in .