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Research project

GR/S23513/01

Project overview

The proposal described below is fundamentally a new method of synthesising, screening and sequencing DNA at a rate that is thousands of time,, faster than existing methods. If successful it will allow over 4 billion bases to be sequenced in less than a day on one instrument! The magnitude what is being proposed here is quite literally mind-boggling and will cause a revolution in all areas of human health forever changing the landscape biological and medicinal sciences. En route spin off applications will include the rapid and comprehensive identification of all single base changes a given person's genome, the ability to analyse large numbers of people for the presence of single changes at an unprecedented rate, a method fl rapidly and cheaply producing huge numbers (100,000s) of defined oligonucleotide sequences, and the use of this methodology to change curren array technology as well as the ultimate aim of sequencing billions of bases a day.

Staff

Lead researchers

Professor Hywel Morgan MBE

Professor of Bioelectronics
Research interests
  • Microfluidics
  • Bio-sensors
  • Lab-on-a-chip technologies
Connect with Hywel

Email: hm@ecs.soton.ac.uk

Other researchers

Professor Jonathan Essex

Professor
Research interests
  • Molecular simulations of biological systems
  • Computer aided drug discovery
  • Method development in molecular simulations
Connect with Jonathan

Email: J.W.Essex@soton.ac.uk

Dr Iris Nandhakumar

Associate Professor
Research interests
  • Scanning Probe Microscopy
  • Carbon nanotubes
  • Nanoscale materials
Connect with Iris

Email: iris@soton.ac.uk

Professor Adam Prugel-Bennett

Prof of Electronics & Computer Science
Connect with Adam

Email: apb@ecs.soton.ac.uk

Professor Nikolay Zheludev

Professor of Physics & Astronomy
Connect with Nikolay

Email: niz@orc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

S.W. Birtwell, G.R. Broder, P.L. Roach & H. Morgan, 2012, Biomedical Microdevices, 14(4), 651-657
DOI:
Type: article
Graham R. Broder, Rohan T. Ranasinghe, Cameron Neylon, Hywel Morgan & Peter L. Roach, 2011, Analytical Chemistry, 83(6), 2005-2011
DOI:
Type: article
Sam Birtwell & Hywel Morgan, 2009, Integrative Biology, 1(5), 337-436
Type: article
Sam W. Birtwell, Shahanara Banu, Nikolay I. Zheludev & Hywel Morgan, 2009, Journal of Physics D: Applied Physics, 42(5), 55507
DOI:
Type: article
S.W. Birtwell, G.S. Galitonov, H. Morgan & N.I. Zheludev, 2008, Optics Communications, 281(7), 1789-1795
DOI:
Type: article
Graham R. Broder, Rohan T. Ranasinghe, Joseph K. She, Shahanara Banu, Sam W. Birtwell, Gabriel Cavalli, Gerasim S. Galitonov, David Holmes, Hugo F.P. Martins, Kevin F. MacDonald, Cameron Neylon, Nikolay Zheludev, Peter L. Roach & Hywel Morgan, 2008, Analytical Chemistry, 80(6), 1902-1909
DOI:
Type: article
Shahanara Banu, Sam Birtwell, Gerasim Galitonov, Yifang Chen, Nikolay Zheludev & Hywel Morgan, 2007, Journal of Micromechanics and Microengineering, 17(7), S116-S121
DOI:
Type: article