B Linclau - IB Catalyst - BB/M028941/1 | University of Southampton

Research project

B Linclau - IB Catalyst - BB/M028941/1

Research groups:

Chemical Biology, Diagnostics and Therapeutics

Organic Chemistry, Synthesis, Catalysis
Other researchers:

Dr Seung Lee
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Project overview

This project will investigate the enzymatic glycosylation of modified carbohydrate monosaccharides to achieve larger, biologically relevant glycan structures. This will be achieved by extensive screening of glycosyltransferase enzymes (enzymes that catalyse the addition of a new monosaccharide to a growing sugar 'acceptor'), that are able to use modified sugars as the 'acceptor', but also as 'donor'. The biological relevance of the synthesised new type of glycan structures will be validated by investigating their binding profile to a range of proteins that are known to be of relevance in the health sciences, with the immediate aim to develop new diagnostics applications. However, depending on the array results, further applications in other areas in the health sciences are envisaged.

Staff

Other researchers

Dr Seung Lee

Associate Professor

Research interests

Chemical biology
Antimicrobial resistance
Glycan processing enzymes

Connect with Seung

Email: S.S.Lee@soton.ac.uk

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

2020, Cell Chemical Biology, 27(9), 1199-1206.e5

DOI:

Type: article

Pablo Valverde Sanchez, Jean B Vendeville, Kristian Hollingsworth, Ashley Mattey, Tessa Keenan, Harriet Chidwick, Helene Ledru, Kler Huonnic, Kun Huang, Mark Light, Nicholas Turner, Jesus Jimenez-Barbero, M. Carmen Galan, Martin A. Fascione, Sabine L. Flitsch, W. Bruce Turnbull & Bruno Linclau, 2020, Chemical Communications, 56(47), 6408-6411

DOI:

Type: article

Claire Council, Kelly J. Kilpin, Jessica S Gusthart, Sarah A. Allman, Bruno Linclau & Seung Seo Lee, 2020, Organic & Biomolecular Chemistry, 18(18), 3423-3451

DOI:

Type: article

2019, ACS Chemical Biology, 14(7), 1660-1671

DOI:

Type: article

Julien GJ Malassis, Jean Vendeville, Qui-Hien Nguyen, Marie Boujon, Quentin Gaignard-Gaillard, Mark Light & Bruno Linclau, 2019, Organic & Biomolecular Chemistry

DOI:

Type: article

Clement Q. Fontenelle, Ramakrishna Kuppala, Mark Light & Bruno Linclau, 2018, Carbohydrate Research, 455, 14-17

DOI:

Type: article

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