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Research project

Hanson RG/15/17/31749 Epigenetic Biomarkers and Determinants of Cardiovascular Risk in Children

Project overview

This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.

Staff

Lead researchers

Emeritus Professor Mark Hanson

Research interests
  • Developmental Origins of Health and Disease (DOHaD)
  • Maternal and Child Health
  • Developmental nutrition and epigenetic mechanisms
Connect with Mark

Email: M.Hanson@soton.ac.uk

Other researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology
Research interests
  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hi…
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone miner…
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Professor Keith Godfrey

Associate Dean – KEE
Connect with Keith

Email: kmg@mrc.soton.ac.uk

Emeritus Professor Hazel Inskip MSc, PhD, FFPH

Connect with Hazel

Email: hmi@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

N. Robinson, H. Brown, Elie Antoun, Keith Godfrey, Mark Hanson, Karen Lillycrop, Sarah Crozier, Robert Murray, M.S. Pearce, C.L. Relton, V. Albani & J.A. McKay, 2021, Clinical Epigenetics, 13(1)
DOI:
Type: article
See Ling Loy, Chee Wai Ku, Ada En Qi Lai, Xin Hui Choo, Angela Hui Min Ho, Yin Bun Cheung, Keith Godfrey, Yap-Seng Chong, Peter D. Gluckman, Lynette Pei-Chi Shek , Kok Hian Tan, Fabian Yap, Shiao-Yng Chan & Jerry Kok Yen Chan, 2021, Fertility and Sterility, 115(1), 138-147
DOI:
Type: article
Anne H.Y. Chu, Rohan Lewis & Keith Godfrey, 2021, International Journal of Obesity, 45(1), 247-257
DOI:
Type: article
Anne H.Y. Chu, I.M. Aris, Sharon Ng, Jonathan Y. Bernard, Tint Mya, Wen Lun Yuan, Keith Godfrey, Jerry Kok Yen Chan, Lynette P. Shek, Yap-Seng Chong, K.H. Tan, Seng Bin Ang, H.H. Tan, Bernard SM Chern, Fabian Yap, Yung Seng Lee, Ngee Lek, Melvin Khee-Shing Leow, Chin Meng Khoo & Shiao-Yng Chan, 2020, Scientific Reports, 10(1)
DOI:
Type: article
Delicia Shu-Qin Ooi, Cheryl Pei-Ting Tan, Michelle Jia-Yu Tay, Siong Gim Ong, Elizabeth Huiwen Tham, Kewin Tien Ho Siah, Johan Gunnar Eriksson, Keith Godfrey, Lynette Pei-Chi Shek & Evelyn Xiu-Ling Loo, 2020, Journal of Developmental Origins of Health and Disease, 11(6), 545-556
DOI:
Type: article
Evelyn X.L. Loo, S.E. Soh, See Loy, Sharon Ng, M.T. Tint, Shiao-Yng Chan, Jonathan Y. Huang, Fabian Yap, K.H. Tan, Bernard S.M. Chern, H.H. Tan, Michael Meaney, Neerja Karnani, Keith Godfrey, Yung Seng Lee, Jerry Kok Yen Chan, Peter D. Gluckman, Y-S Chong, Lynette P. Shek & Johan G. Eriksson, 2020, European Journal of Epidemiology
DOI:
Type: article
Reshma Appukuttan Pillai, Mohammed Omedul Islam, Preben Selvam, Neha Sharma, Anne HY Chu, Oliver C. Watkins, Keith Godfrey, Rohan Lewis & Shiao-Yng Chan, 2020, Journal of Clinical Endocrinology & Metabolism, 106(2), e875–e890
DOI:
Type: article