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Research project

Hanson RG/15/17/31749 Epigenetic Biomarkers and Determinants of Cardiovascular Risk in Children

Project overview

This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.

Staff

Lead researchers

Emeritus Professor Mark Hanson

Research interests
  • Developmental Origins of Health and Disease (DOHaD)
  • Maternal and Child Health
  • Developmental nutrition and epigenetic mechanisms
Connect with Mark

Email: M.Hanson@soton.ac.uk

Other researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology
Research interests
  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hi…
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone miner…
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Professor Keith Godfrey

Associate Dean – KEE
Connect with Keith

Email: kmg@mrc.soton.ac.uk

Emeritus Professor Hazel Inskip MSc, PhD, FFPH

Connect with Hazel

Email: hmi@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Peter D. Gluckman, Felicia M. Low & Mark A. Hanson, 2020, Evolution, Medicine, and Public Health, 2020(1), 304-310
DOI:
Type: letterEditorial
Elie Antoun, Negusse T. Kitaba, Philip Titcombe, Kathryn V. Dalrymple, Emma S. Garratt, Sheila J. Barton, Robert Murray, Paul T. Seed, Joanna D. Holbrook, Michael S. Kobor, David Ts Lin, Julia L. Macisaac, Graham C. Burdge, Sara L. White, Lucilla Poston, Keith M. Godfrey & Karen A. Lillycrop, 2020, PLoS Medicine, 17(11)
DOI:
Type: article
Elizabeth Taylor, Sam Wilding, Nida Ziauddeen, Keith Godfrey, Ann Berrington & Nisreen Alwan, 2020, Obesity Reviews, 21(11)
DOI:
Type: article
Martin O'Donnell, Janis Baird, Cyrus Cooper, Sarah Crozier, Keith Godfrey, Michael Geary , Hazel Inskip & Catherine B. Hayes, 2020, International Journal of Environmental Research and Public Health, 17(21), 7991
DOI:
Type: article
Hazel Inskip, Sarah Crozier, Janis Baird, Julia Hammond, Sian Robinson, Cyrus Cooper & Keith Godfrey, 2020, Journal of the Developmental Origins of Health and Disease
DOI:
Type: article
Angelina Lessa, Ada Garcia, Pauline Emmett, Sarah Crozier, Sian M Robinson, Keith Godfrey & Charlotte M. Wright, 2020, Maternal & Child Nutrition, 16(4)
DOI:
Type: article
Tessa J. Roseboom, Susan E. Ozanne, Keith Godfrey, Carmen R. Isasi, Hiroaki Itoh, Rebecca Simmons , Amita Bansal, Mary Barker, Torsten Plosch, Deborah M. Sloboda, Stephen G. Matthews, Caroline Fall, Lucilla Poston & Mark Hanson, 2020, Journal of the Developmental Origins of Health and Disease, 12(1), 3-5
DOI:
Type: article